3-D Motion Estimation and Wireframe Adaptation Including Photometric Effects for Model-Based Coding of Facial Image Sequences

Cataloged from PDF version of article.We propose a novel formulation where 3-D global and local motion estimation and the adaptation of a generic wireframe model to a particular speaker are considered simultaneously within an optical flow based framework including the photometric effects of the motion. We use a flexible wireframe model whose local structure is characterized by the normal vectors of the patches which are related to the coordinates of the nodes. Geometrical constraints that describe the propagation of the movement of the nodes are introduced, which are then efficiently utilized to reduce the number of independent structure parameters. A stochastic relaxation algorithm has been used to determine optimum global motion estimates and the parameters describing the structure of the wireframe model. Results with both simulated and real facial image sequences are provided

An adaptive speckle suppression filter for medical ultrasound imaging

Cataloged from PDF version of article.An adaptive smoothing technique for speckle suppression in medical B-scan ultrasonic imaging is presented. The technique is based on filtering with appropriately shaped and sized local kernels. For each image pixel, a filtering kernel, which fits to the local homogeneous region containing the processed pixel, is obtained through a local statistics based region growing technique. Performance of the proposed filter has been tested on the phantom and tissue images. The results show that the filter effectively reduces the speckle while preserving the resolvable details. The simulation results are presented in a comparative way with two existing speckle suppression methods. © 1995 IEE

An improvement to MBASIC algorithm for 3D motion and depth estimation

Cataloged from PDF version of article.In model-based coding of facial images, the accuracy of motion and depth parameter estimates strongly affects the coding efficiency. MBASIC is a simple and effective iterative algorithm (recently proposed by Aizawa et al.) for 3-D motion and depth estimation when the initial depth estimates are relatively accurate. In this correspondence, we analyze its performance in the presence of errors in the initial depth estimates and propose a modification to MBASIC algorithm that significantly improves its robustness to random errors with only a small increase in the computational load

Enhancement of images corrupted with signal dependent noise: Application to ultrasonic imaging

An adaptive filter for smoothing images corrupted by signal dependent noise is presented. The filter is mainly developed for speckle suppression in medical B-scan ultrasonic imaging. The filter is based on mean filtering of the image using appropriately shaped and sized local kernels. Each filtering kernel, fitting to the local homogeneous region, is obtained through local statistics based region growing. Performance of the proposed scheme have been tested on a B-scan image of a standard tissue-mimicking ultrasound resolution phantom. The results indicate that the filter effectively reduces the speckle while preserving the resolvable details. The performance figures obtained through computer simulations on the phantom image are presented in a comparative way with some existing speckle iippression schemes

Simultaneous 3-D motion estimation and wire-frame model adaptation including photometric effects for knowledge-based video coding

We address the problem of 3-D motion estimation in the context of knowledge-based coding of facial image sequences. The proposed method handles the global and local motion estimation and the adaptation of a generic wire-frame to a particular speaker simultaneously within an optical flow based framework including the photometric effects of motion. We use a flexible wire-frame model whose local structure is characterized by the normal vectors of the patches which are related to the coordinates of the nodes. Geometrical constraints that describe the propagation of the movement of the nodes are introduced, which are then efficiently utilized to reduce the number of independent structure parameters. A stochastic relaxation algorithm has been used to determine optimum global motion estimates and the parameters describing the structure of the wire-frame model. For the initialization of the motion and structure parameters, a modified feature based algorithm is used. Experimental results with simulated facial image sequences are given. © 1994 IEEE

Digital computation of the fractional fourier transform

An algorithm for efficient and accurate computation of the fractional Fourier transform is given. For signals with time-bandwidth product N, the presented algorithm computes the fractional transform in O(JVlogjY) time. A definition for the discrete fractional Fourier transform that emerges from our analysis is also discussed. © 1996 IEEE

Rapid and objective assessment of neural function in autism spectrum disorder using transient visual evoked potentials

OBJECTIVE: There is a critical need to identify biomarkers and objective outcome measures that can be used to understand underlying neural mechanisms in autism spectrum disorder (ASD). Visual evoked potentials (VEPs) offer a noninvasive technique to evaluate the functional integrity of neural mechanisms, specifically visual pathways, while probing for disease pathophysiology. METHODS: Transient VEPs (tVEPs) were obtained from 96 unmedicated children, including 37 children with ASD, 36 typically developing (TD) children, and 23 unaffected siblings (SIBS). A conventional contrast-reversing checkerboard condition was compared to a novel short-duration condition, which was developed to enable objective data collection from severely affected populations who are often excluded from electroencephalographic (EEG) studies. RESULTS: Children with ASD showed significantly smaller amplitudes compared to TD children at two of the earliest critical VEP components, P60-N75 and N75-P100. SIBS showed intermediate responses relative to ASD and TD groups. There were no group differences in response latency. Frequency band analyses indicated significantly weaker responses for the ASD group in bands encompassing gamma-wave activity. Ninety-two percent of children with ASD were able to complete the short-duration condition compared to 68% for the standard condition. CONCLUSIONS: The current study establishes the utility of a short-duration tVEP test for use in children at varying levels of functioning and describes neural abnormalities in children with idiopathic ASD. Implications for excitatory/inhibitory balance as well as the potential application of VEP for use in clinical trials are discussed

High Proportion of 22q13 Deletions and SHANK3 Mutations in Chinese Patients with Intellectual Disability

Intellectual disability (ID) is a heterogeneous disorder caused by chromosomal abnormalities, monogenic factors and environmental factors. 22q13 deletion syndrome is a genetic disorder characterized by severe ID. Although the frequency of 22q13 deletions in ID is unclear, it is believed to be largely underestimated. To address this issue, we used Affymetrix Human SNP 6.0 array to detect the 22q13 deletions in 234 Chinese unexplained ID patients and 103 controls. After the Quality Control (QC) test of raw data, 22q13 deletions were found in four out of 230 cases (1.7%), while absent in parents of the cases and 101 controls. A review of genome-wide microarray studies in ID was performed and the frequency of 22q13 deletions from the literatures was 0.24%, much lower than our report. The overlapping region shared by all 4 cases encompasses the gene SHANK3. A heterozygous de novo nonsense mutation Y1015X of SHANK3 was identified in one ID patient. Cortical neurons were prepared from embryonic mice and were transfected with a control plasmid, shank3 wild-type (WT) or mutant plasmids. Overexpression of the Y1015 mutant in neurons significantly affected neurite outgrowth compared with shank3 WT. These findings suggest that 22q13 deletions may be a more frequent cause for Chinese ID patients than previously thought, and the SHANK3 gene is involved in the neurite development

Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling

The chronic effects of cocaine abuse on brain structure and function are blamed for the inability of most addicts to remain abstinent. Part of the difficulty in preventing relapse is the persisting memory of the intense euphoria or cocaine “rush”. Most abused drugs and alcohol induce neuroplastic changes in brain pathways subserving emotion and cognition. Such changes may account for the consolidation and structural reconfiguration of synaptic connections with exposure to cocaine. Adaptive hippocampal plasticity could be related to specific patterns of gene expression with chronic cocaine abuse. Here, we compare gene expression profiles in the human hippocampus from cocaine addicts and age-matched drug-free control subjects. Cocaine abusers had 151 gene transcripts upregulated, while 91 gene transcripts were downregulated. Topping the list of cocaine-regulated transcripts was RECK in the human hippocampus (FC = 2.0; p<0.05). RECK is a membrane-anchored MMP inhibitor that is implicated in the coordinated regulation of extracellular matrix integrity and angiogenesis. In keeping with elevated RECK expression, active MMP9 protein levels were decreased in the hippocampus from cocaine abusers. Pathway analysis identified other genes regulated by cocaine that code for proteins involved in the remodeling of the cytomatrix and synaptic connections and the inhibition of blood vessel proliferation (PCDH8, LAMB1, ITGB6, CTGF and EphB4). The observed microarray phenotype in the human hippocampus identified RECK and other region-specific genes that may promote long-lasting structural changes with repeated cocaine abuse. Extracellular matrix remodeling in the hippocampus may be a persisting effect of chronic abuse that contributes to the compulsive and relapsing nature of cocaine addiction

Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

Abstract The scaffold protein DLGAP1 is localized at the post-synaptic density (PSD) of glutamatergic neurons and is a component of supramolecular protein complexes organized by PSD95. Gain-of-function variants of DLGAP1 have been associated with obsessive-compulsive disorder (OCD), while haploinsufficient variants have been linked to autism spectrum disorder (ASD) and schizophrenia in human genetic studies. We tested male and female Dlgap1 wild type (WT), heterozygous (HT), and knockout (KO) mice in a battery of behavioral tests: open field, dig, splash, prepulse inhibition, forced swim, nest building, social approach, and sucrose preference. We also used biochemical approaches to examine the role of DLGAP1 in the organization of PSD protein complexes. Dlgap1 KO mice were most notable for disruption of protein interactions in the PSD, and deficits in sociability. Other behavioral measures were largely unaffected. Our data suggest that Dlgap1 knockout leads to PSD disruption and reduced sociability, consistent with reports of DLGAP1 haploinsufficient variants in schizophrenia and ASD